Exploring the relationship between cognitive impairment and characteristic Lead Investigator: Morgan Schwartz Institution : Smith College E-Mail : mschwartz@smith.edu Proposal ID : 814 Proposal Description: We are interested in the relationship between the pathology associated with Alzheimer's Disease and its impact on cognitive impairment. Aim 1: To determine if AD pathology (amyloid plaques and neurofibrillary tangles) predicts an AD diagnosis and/or the severity of cognitive impairment Aim 2: To explore what distinguishes cognitively normal patients with AD pathology from those with AD Aim 3: To identify other risk factors or diagnoses that correlate with amyloid plaques and neurofibrillary tangles